ABSTRACT
A follicular mycosis fungoides(FMF) is an unusual clinical and histological variant of mycosis fungoides(MF), characterized by selective involvement of hair follicles by atypical lymphocytes with folliculotropism. FMF is more refractory to treatment, and has a worse prognosis than classic MF. We report a case of FMF presenting as follicular papules on the left forearm in a 43-year-old man. Histologic findings showed an infiltration of mycosis cells within and around follicles and Pautrier's microabscess in the follicular epithelium without mucinosis.
Subject(s)
Adult , Humans , Epithelium , Forearm , Hair Follicle , Lymphocytes , Mucinoses , Mycosis Fungoides , PrognosisABSTRACT
Dehydroepiandrosterone(DHEA) was administered to rats to investigate the efficacy of DHEA in prevention of the process of osteoporosis induced by oophorectomy. Female Sprague-Dawley rats, aged five months, were divided into three groups; Group 1(40 rats), sham operation as control; group 2(40 rats), bilateral oophorectomy; and group 3(20 rats), intraperitoneal injection of 10mg of DHEA every other day from 4 weeks after bilateral oophorectomy. In group 1 and 2, five rats of each group were sacrificed weekly until the 8th week. In group 3, five rats were killed weekly from 1 week to 4 weeks after DHEA administration. Trabecular bone area(TBA) of proximal metaphysic of left tibia was obtained by quantitative image analysis system. In group 1, TBA was not changed with time after sham operation, In group 2, TBA decreased progressively through eight weeks after oophorectomy. In group 3, TBA’s were higher than those of group 2, but they were still lower than those of group 1. These data suggested that DHEA, administered to rats from 4 weeks to 8 weeks after bilateral oophorectomy, may partially recover the osteoporosis or delay the progression of the osteoporotic change until 8 weeks after the oophorectomy.
Subject(s)
Animals , Female , Humans , Rats , Dehydroepiandrosterone , Injections, Intraperitoneal , Metaphysics , Osteoporosis , Ovariectomy , Rats, Sprague-Dawley , TibiaABSTRACT
No abstract available.
ABSTRACT
The developing process of the hair of the fetal skin was studied. The ages of 103 human embryos and fetuses ranged from 4 to 40 gestation weeks. Ten different sites were selected, i.e., scalp, forehead, cheek, chest, abdomen, back, palm, sole, finger and toe. For the embryos 3 sites were studied, i.e., cephalic, trunk, and caudal portions. Following results were made: 1) The primitive hair germ was first noted the 10th week in the face skin as nubbins of mesenchymal cells beneath discrete foci of crowdes, elongated germinative epithelial cells. The developing hair germs and hair pegs were observes at the cephalic portion by 11 weeks. At 15 weeks the hair pegs including hair germs were noted in the trunk skin. The bulbous hair peg stage started at the 16th week in the cephalic portion and at the 18th week in the trunk. 2) Relative number of fetal hairs progressively increase up to 20 weeks of gestation but, thereafter decreased although it was different by the site of the body. 3) The diameter of fetal hair follicles increased with fetal age to the term with slight difference by the portion of body. 4) The developmental process of hair was more rapid in the cephalic portion than the trunk in views of morphologic changes of the hair structures, number and diameter of hair follicles.